循证医学及屠呦呦获奖后传统医学的研究潮E

MiMT学势医学培训中心第篇文章

keywords:

Evidence-basedMedicine(EBM)循证医学

paediatric/paediatrician儿科的/儿科医生

broth清汤(肉汤)

antipyretic退烧的；Efficacy疗效

aliquot（化验的）试样；assay化验

循证医学及屠呦呦获奖后传统医学研究潮

EngagechildrenwithEvidence-basedMedicineAstrategytoengagechildrenofethnicminorityfamilieswithevidence-basedmedicineintheUK.ResearchcarriedoutinasingleprimaryschoolthereprovidedthedataforpublicationintheSCIpaediatricjournal‘ArchivesofDiseasesinChildhood’recently(ref).

TheauthorsnotethatsincetheincorporationoftheQinghaoherbfromChinaintofront-lineantimalarialagents,

therehasbeen‘aresurgenceofinterestinscreeningnaturalproductlibrariesforotherpotentialsourcesofantimalarialsandconsultingwithtraditionalhealerstofindunexploredchemicalspaceforfuturedrugdiscovery.’

Theygoon:‘liketheuseofQinghao,manytraditionalculturesprescribeahotbrothfortreatingfever,eachhavingascribedmiraculouspowersofhealing.’

Londonisamelting-potofcultures.

Childrenfromnon-Britishbackgroundsatasingleprimaryschoolwereaskedtoprovidebrothsfromtheirfamilywhich,accordingtotheirfamily’saccumulatedculturalknowledge,couldbeeffectiveasanantipyretic(退热的).

Atotalof56clearbrothsweresubmittedbychildrenfromfamiliesderivedfromofpartsofEurope,NorthAfricaandtheMiddleEast.

Aliquotsofthesewerefrozenandthenfiltered.

Filtrateswereassayedtoidentifypossibleantimalarialactivityattwopoints(1)and(2)inthemalarialparasitelife-cycle(seediagram).

Dihydroartemisinin(DHA)istheactiveingredientderivedfromtheQinghaoherbdiscoveredbyNobelPrizewinnerTuYouYou.TheauthorsuseDHAasapositivecontrolinoneoftheirassays.

Diagram:Life-cycleofthemalarialparasitePlasmodiumfalciparum

Althoughmostbrothscausedeithernoeffectonthein-vitrogrowthofP.falciparum,severalcausedincreasedgrowth(duetothepresenceofobviousnutrients),andafewreducedgrowthby50%ormore.

TwofiltrateswerealmostaseffectiveastheDHApositivecontrolininhibitingproliferationofthemalarialparasite.

Thefamilieswerenotaskedtoprovidethepreciserecipes,howevertheresearchersfoundthatthetwomostusefulbrothscouldbeeithermeat-basedorvegetablebased(specificallyderivedfromchickenandred-cabbage).

Theauthorsdiscussthatthisexercise‘demonstratesthepowerofsimpleclassroom-basedexercisesinengagingchildreninthenormallydisparatedisciplinesoftraditionalmedicineorremediesandlaboratoryorevidenced-basedresearch.

Atatimewhenthereisaresurgentvoiceagainstevidence-basedmedicine,suchexerciseshavegreatimportanceforeducatingthenextgenerationabouthownewdrugsarediscovered,howtheymightworkandhowuntappedresourcesstillexistinthefightagainstglobaldiseasesofsignificance’.PersonalviewfromDanielPorter:

Itseemsunlikelythatprimaryschoolchildrenacrosstheworldcouldbe

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